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A mathematical model of steady state B lymphopoiesis in mouse and rat bone marrow /

In this study, we have analyzed the steady-state kinetics of B lymphocytes in mouse and rat bone marrow using previously published experimental data. Over many years, Prof D.G. Osmond and his colleagues have built up a scheme of B cell development in mouse bone marrow based on the sequential expression of markers associated with the B lineage. The earliest precursor B cells comprise three populations of proliferating pro-B cells, i.e. early, intermediate, and late pro-B cells. The subsequent populations comprise pre-B cells that give rise to nondividing B lymphocytes expressing surface IgM. / In our analysis, we have checked the available published data for consistency with the proliferation of precursor B cells and their death via apoptosis at certain stages of cell development. We made an extensive summary of the existing data on the various B cell precursors and organized it into a comprehensible framework. We built a mathematical model for the proliferation and differentiation of mammalian B lymphocytes in laboratory mice and rats and estimated all of the parameters to explain the existing steady state data. In this context, mathematical modeling acts as a useful tool to analyze hypotheses and experimental results concerning the steady state numbers of B lymphocytes.

Identiferoai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.101854
Date January 2007
CreatorsKaranfil, Özge.
PublisherMcGill University
Source SetsLibrary and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada
LanguageEnglish
Detected LanguageEnglish
TypeElectronic Thesis or Dissertation
Formatapplication/pdf
CoverageMaster of Science (Department of Physiology.)
Rights© Özge Karanfil, 2007
Relationalephsysno: 002653255, proquestno: AAIMR38405, Theses scanned by UMI/ProQuest.

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