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Alternative splicing of the zebrafish myosin phosphatase targeting subunit, MYPT1, produces a novel isoform

Alternative splicing of the zebrafish Myosin Phosphatase Targeting Subunit, MYPT1, produces a novel isoform (TV202). TV202 and the truncated TV202Δ ere shown to form an active complex with Protein Phosphatase 1 β (PP1β) via stress fiber assay. TV202 was also shown to be localized in the cytoplasm, enriched in a paranuclear manner. TV202Δ was found the be localized inside the nucleus. It was also found that TV202 was zygotically, but not maternally, expressed during early zebrafish development via RT-PCR.

Identiferoai:union.ndltd.org:pacific.edu/oai:scholarlycommons.pacific.edu:uop_etds-1172
Date01 January 2016
CreatorsYoung, Kyle E.
PublisherScholarly Commons
Source SetsUniversity of the Pacific
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceUniversity of the Pacific Theses and Dissertations
Rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/

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