Fast field-cycling MRI (FFC-MRI) is a novel technique that promises to expand upon the diagnostic capabilities of conventional MRI by allowing the main magnetic field, B0, to be varied during the imaging pulse sequence. By doing this it is possible to gain access to information that is hidden to conventional scanners - namely the variation of the spin-lattice relaxation time, T1, with field strength, known as T1 dispersion. However, adding B0 as a new dimension to the imaging process necessitates a longer scan time which can limit the techniques application to clinical research. In this thesis, several methods are explored for reducing FFC-MRI scan times. A rapid imaging pulse sequence based on the well-known Fast Spin-Echo imaging sequence is presented, as well as an adaptation of the “keyhole” acquisition strategy. A method of determining T1 which requires significantly less data - and hence scan time - is also presented. When combined, these techniques are demonstrated to reduce total scan time from several hours to minutes without compromising access to T1 dispersion information. The techniques are demonstrated in phantom studies and in vivo results from volunteers are presented as proof of concept. The reduction in scan time demonstrated by these methods will significantly improve the applicability of FFC-MRI for clinical trials which are currently being worked towards.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:693273 |
| Date | January 2016 |
| Creators | Ross, Peter James |
| Publisher | University of Aberdeen |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=230548 |
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