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Effects of dietary fatty acids on cholesterol content, and fatty acid distributions in total and phospholipid fractions of mammary glands and adenocarcinomas from strain A/St mice

This study was designed to determine the distribution of fatty acids and cholesterol in total tumor and mammary tissues. Fatty acid profiles of phospholipid fractions from tumors and mammary glands were also determined. Fatty acids and cholesterols were analyzed by gas liquid chromatography. Methodology was developed for phospholipid separation by high performance liquid chromatography.Tumors derived from mammary glands in Strain A/ST mice were found to contain two to three times the amount of cholesterol compared to normal mammary glands. Mammary glands from safflower fed mice contained significantly higher percentages of linoleic acid. Linoleic acid content in stearicacid (SA-1) fed mice was sharply reduced. linoleic acid in mammary glands of animals fed a high fat Stearic acid (SA-4) , corn oil and stock diet fed animals displayed similar fatty acid profiles. Fatty acid analysis of tumors excised from mice fed the experimental diets showed similar patterns in comparison to normal mammary glands. The similar distributions were in the 18 carbon fatty acids. Distributions of phospholipid fatty acids in tumors and mammary glands were similar. Mammary gland phospholipids displayed increased percentages of short chain (14 carbons and under) fatty acids. Results of these studies demonstrate an increased availability of diet rich in polyunsaturated fatty acids.

Identiferoai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/183178
Date January 1986
CreatorsSmith, Scott Alan
ContributorsBennett, Alice S.
Source SetsBall State University
Detected LanguageEnglish
Formatvii, 73 leaves : ill. ; 28 cm.
SourceVirtual Press

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