This thesis consists of three manuscripts, which are presented in chapters 2, 3 and 4. The first manuscript (chapter 2) is a protocol for systematic review which outlines the steps used to systematically analyze the literature with regards to the primary objective of reviewing available evidence. The second manuscript (chapter 3) is the presentation of systematic review and meta-analysis in the form of a manuscript to be submitted for peer-review by fall 2020. The third manuscript (chapter 4) summarizes an analysis of CHILD study data that assesses the association of dietary patterns with infant wheeze and asthma through age 3. In chapter 5, the thesis concludes by summarizing study limitations, epidemiological implications, clinical relevance of these findings and future directions. Appendices are also included to highlight research methodology and describe comprehensively all data analyses. / Thesis / Master of Science (MSc) / This paper-based thesis includes my graduate research work to satisfy the requirements for a masters in science (M.Sc.) degree in the Medical Sciences department. The focus of this thesis is to contribute an important study of the role of maternal and infant nutrition in the development of asthma and wheeze in children. My research findings are presented as original manuscripts of a systematic review protocol, systematic review, and a primary analysis of data collected as part of the CHILD longitudinal birth cohort study. At present, the first 2 manuscripts are under review by scientific journals; and the third will be submitted for peer-review in October 2021.
| Identifer | oai:union.ndltd.org:mcmaster.ca/oai:macsphere.mcmaster.ca:11375/27375 |
| Date | January 2021 |
| Creators | Gulacha, Pinaz |
| Contributors | de Souza, Russell, Medical Sciences |
| Source Sets | McMaster University |
| Language | English |
| Detected Language | English |
| Type | Thesis |
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