The role of meat consumption in the development of cancer, including colorectal cancer (CRC), has been subject of much investigation in recent years. The observation of geographical variation in CRC incidence and increased CRC risks in populations consuming high levels of meat prompted researchers to hypothesise a link between meat and CRC. An area of particular interest in CRC pathogenesis is the meat-derived compounds such are heterocyclic amines (HCAs), polycyclic aromatic hydrocarbons (PAHs), and meatderived mutagenic activity. Australia is among the countries with high incidence of CRC and also high levels of per capita meat consumption. Hence, clarifying the possible link between meat consumption and the risk of CRC in order that this can be translated into preventive dietary recommendations for the public is important. The objective of this thesis was to examine whether meat consumption is related to risk of CRC in an Australian population. The term meat consumption in this thesis means meaures of consumption of red and white meat that incorporate frequency and cooking method. The following hypotheses were investigated: 1. Increasing intake of meat prepared by methods that involve higher cooking temperature and time is positively associated with the risk of CRC; 2. Increasing exposure to meat-derived heterocyclic amines (HCAs) is positively associated with the risk of CRC; 3. Higher levels of exposure to polycyclic aromatic hydrocarbons (PAHs) from meat consumption is a risk factor for CRC; 4. Exposure to meat-derived mutagens increases the risk of CRC.
| Identifer | oai:union.ndltd.org:ADTP/281378 |
| Date | January 2009 |
| Creators | Tabatabaei, Seyed Mehdi |
| Publisher | University of Western Australia. School of Population Health |
| Source Sets | Australiasian Digital Theses Program |
| Language | English |
| Detected Language | English |
| Rights | Copyright Seyed Mehdi Tabatabaei, http://www.itpo.uwa.edu.au/UWA-Computer-And-Software-Use-Regulations.html |
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