The aim of this diploma thesis was to study the structure and to evaluate the properties of the hydrogel prepared by the interaction of the aminolclay with the biopolymer. Representatives of the biopolymers were selected from low to medium molecular weight sodium hyaluronate and sodium polystyrenesulfonate. On the basis of the experiments carried out, it was found that phase separation takes place only when the aminolclay interacts with medium molecular weight hyaluronan (MMW). In the experimental part, analyzes of this sample were carried out in order to determine the formation of phase-separated hydrogel by influencing the solution by ionic strength, investigation of hydrogel extinction in various organic solvents, stability of hydrogel under extreme temperature conditions, the effect of storage on its degradation, etc. Viscoelastic properties were experimentally proven by rheology and thermal analysis detected binding water. Inhibition of microorganisms was confirmed by antibacterial diffusion assays. All experiments were carried out for the use of the Aj-HyA hydrogel (MMW) in the field of medical applications, specifically for the modern method of wet wound healing of the skin.
| Identifer | oai:union.ndltd.org:nusl.cz/oai:invenio.nusl.cz:316185 |
| Date | January 2017 |
| Creators | Plotěná, Michaela |
| Contributors | Pekař, Miloslav, Mravec, Filip |
| Publisher | Vysoké učení technické v Brně. Fakulta chemická |
| Source Sets | Czech ETDs |
| Language | Czech |
| Detected Language | English |
| Type | info:eu-repo/semantics/masterThesis |
| Rights | info:eu-repo/semantics/restrictedAccess |
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