Medical image analysis is one of the most critical studies in field of medicine, since results gained by the analysis guide radiologists for diagnosis, treatment planning, and verification of administered treatment. Therefore, accuracy in analysis of medical images is at least as important as accuracy in data acquisition processes.
Medical images require sequential application of several image post-processing techniques in order to be used for quantification and analysis of intended features. Main objective of this thesis study is to build up an application framework, which enables analysis and quantification of several features in medical images with minimized input-dependency over results. Intended application targets to present a software environment, which enables sequential application of medical image processing routines and provides support for radiologists in diagnosis, treatment planning and treatment verification phases of neurodegenerative diseases and brain tumors / thus, reducing the divergence in results of operations applied on medical images.
In scope of this thesis study, a comprehensive literature review is performed, and a new medical image processing and analysis framework - including modules responsible for automation of separate processes and for several types of measurements such as real tumor volume and real lesion area - is implemented. Performance of the fully-automated segmentation module is evaluated with standards introduced by Neuro Imaging Laboratory, UCLA / and the fully-automated registration module with Normalized Cross-Correlation metric. Results have shown a success rate above 90 percent for both of the modules. Additionally, a number of experiments have been designed and performed using the implemented application.
It is expected for an accurate, flexible, and robust software application to be accomplished on the basis of this thesis study, and to be used in field of medicine as a contributor by even non-engineer professionals.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12612965/index.pdf |
| Date | 01 February 2011 |
| Creators | Cevik, Alper |
| Contributors | Eyuboglu, Murat |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | M.S. Thesis |
| Format | text/pdf |
| Rights | To liberate the content for public access |
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