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Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity

The aim of this study is to utilise the tetracycline dependent gene regulation system to down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.

Identiferoai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uct/oai:localhost:11427/10930
Date January 2011
CreatorsMbele, Prisca
ContributorsChapman, Ros, Williamson, Anna-Lise
PublisherUniversity of Cape Town, Faculty of Health Sciences, Division of Virology
Source SetsSouth African National ETD Portal
LanguageEnglish
Detected LanguageEnglish
TypeDoctoral Thesis, Doctoral, PhD
Formatapplication/pdf

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