C-reactive protein, a normally occurring plasma protein, may become elevated as much as 3,000-fold during disease states involving acute inflammation or tissue damage. Through its binding to phosphorylcholine, in the presence of calcium, C-reactive protein has been shown to potentiate the activation of the classical and alternative complement pathways and stimulate phagocytosis as well as inhibit certain platelet and T cell reactivities. Its interaction with the various substances that are an integral part of immunological surveillance implies an important role for C-reactive protein in the host reaction to defense, disease and inflammation. The possible significance of this role is discussed.
| Identifer | oai:union.ndltd.org:nova.edu/oai:nsuworks.nova.edu:occ_stuetd-1022 |
| Date | 01 July 1980 |
| Creators | Mills, Rhonda A |
| Publisher | NSUWorks |
| Source Sets | Nova Southeastern University |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | Theses and Dissertations |
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