Dietary intervention remains a popular, albeit challenging, approach for combating
obesity. In recent years, dietary interventions that increase consumption of
medium-chain triglycerides (MCT) instead of long-chain triglycerides (LCT) have
gained attention. Pre-clinical research has demonstrated that rats fed a
high-fat diet (HFD) induce adiposity, but a dietary shift from LCT to MCT
suppresses this effect. To date, the extent to which this effect operates via
suppressed hyperphagia is not fully understood. In the present study, we sought
to determine how consuming a HFD composed of different fat types affects energy
intake, adiposity, and hippocampal brain-derived neurotropic factor (BDNF)
levels. Rats were assigned to one of four diet groups – rat chow (CHOW),
LCT-enriched HFD (LCT-HFD), MCT-enriched HFD (MCT-HFD), or coconut oil-enriched
HFD (COCO-HFD), which composes a mixture of LCT and MCT. In Experiment 1, all
animals were given <i>ad libitum</i> access
to their assigned diet, whereas in Experiments 2 and 3, HFD-subjects were
pair-fed to CHOW to prohibit hyperphagia. In Experiments 1 and 2, subjects were
aged 20-24 weeks, whereas in Experiment 3, subjects were aged 10-11 weeks.
Across experiments, we found that the effect of MCT consumption on suppressing
HFD-induced adiposity is causally related to suppressed HFD-induced
hyperphagia. Additionally, we failed to detect an
effect of HFD consumption on hippocampal BDNF. Therefore, our findings did not
support or oppose the hypothesis that MCT consumption attenuates HFD-induced
BDNF deficiency. Future studies should focus on determining the causal
relationship between MCT consumption, energy expenditure, and HFD-induced
adiposity.
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/19483865 |
| Date | 19 April 2022 |
| Creators | Brent Benjamin Bachman (12326948) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/THE_IMPACT_OF_MEDIUM-CHAIN_TRIGLYCERIDES_ON_ENERGY_INTAKE_ADIPOSITY_AND_HIPPOCAMPAL_BRAIN-DERIVED_NEUROTROPIC_FACTOR_IN_AD_LIBITUM_AND_PAIR-FED_RAT_MODELS_OF_HIGH-FAT-DIET-INDUCED_OBESITY/19483865 |
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