We investigated age-related differences in neural activation associated with recognition of familiar melodies, a process that requires retrieval from musical semantic memory and leads to a feeling of familiarity. We used sparse sampling fMRI to determine the neural correlates of melody processing and familiarity by comparing activation when listening to melodies versus signal-correlated noise, and to familiar versus unfamiliar melodies, respectively. Overall, activity in the bilateral superior temporal gyrus correlated well with melody processing. Familiarity was associated with several frontal regions (bilateral inferior frontal gyrus, superior frontal gyrus, and precentral gyrus; left insular cortex), right superior temporal gyrus; left supramarginal gyrus and cingulate gyrus; bilateral putamen and thalamus; cerebellum and brainstem. No significant differences were found between younger and older adults for either melody processing or familiarity based activation. Assessment of familiarity-related group differences using less stringent criteria identified plausible areas; greater activation was seen bilaterally in the superior temporal gyrus in younger adults and in some left parietal regions in older adults. This study adds to the knowledge of musical semantic memory with results based on a large sample (N = 40) that includes older adults. Our findings for activation associated with melody processing and familiarity support some, but not all, previous results of related studies. We were unable to find conclusive evidence of age-related differences in neural correlates of musical semantic memory, while also being the first study (to the best of our knowledge) to search for these differences. / Thesis (Master, Neuroscience Studies) -- Queen's University, 2013-09-16 12:38:10.757
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:OKQ.1974/8284 |
| Date | 16 September 2013 |
| Creators | Sikka, Ritu |
| Contributors | Queen's University (Kingston, Ont.). Theses (Queen's University (Kingston, Ont.)) |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English, English |
| Detected Language | English |
| Type | Thesis |
| Rights | This publication is made available by the authority of the copyright owner solely for the purpose of private study and research and may not be copied or reproduced except as permitted by the copyright laws without written authority from the copyright owner. |
| Relation | Canadian theses |
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