The present thesis investigates the effects of lesions to several hypothesized learning and memory systems on the morphine conditioned cue preference on the radial maze. Lesions of the structures thought to be centered to learning systems: the lateral nucleus of amygdala, fornix/fimbria, anterior dorsal striatum and posterior dorsal striatum, were made, In Experiment One, each structure was lesioned separately. Only lesions of the lateral nucleus of amygdala blocked morphine CCP learning. In Experiment Two, rats with combined lesions of fornix/fimbria and dorsal striatum, the lateral nucleus of amygdala and fornix/fimbria, as well as the lateral nucleus of amygdala and dorsal striatum were all impaired on morphine CCP. All of the rats with combined lesions were impaired in this CCP learning. These findings suggest that the lateral nucleus of amygdala is necessary for the morphine CCP. Participation of dorsal striatum or fornix/fimbria is also required. Some hypotheses about the interactions among the structures are discussed.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.27296 |
| Date | January 1996 |
| Creators | Chai, Sin-Chee, 1969- |
| Contributors | White, Norman (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Psychology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001556914, proquestno: MQ29671, Theses scanned by UMI/ProQuest. |
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