The protein synthesis inhibitors cycloheximide and anisomycin were administered during training in an attempt to block the consolidation of the memory for a morphine conditioned place preference. The systemic injection of 2.5mg/kg of cycloheximide post-training failed to block consolidation, though there was a trend towards an attenuated preference, however cycloheximide produced a conditioned place aversion if paired with one compartment. To examine the effect of more complete protein synthesis inhibition and reduce the aversive effects, the less toxic protein synthesis inhibitor anisomycin was infused into the lateral ventricles of the brain either pre-, post- or 3 hours following training. Post-training infusions of anisomycin blocked the formation of a conditioned place preference, while pre-training and 3 hours post-training infusions showed no significant effect over two conditioning pairings. It was concluded that drug conditioning in the place preference paradigm requires protein synthesis for memory consolidation as do other learning paradigms.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.82415 |
| Date | January 2004 |
| Creators | Robinson, Michael, 1980- |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Master of Science (Department of Psychology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 002209935, proquestno: AAIMR12530, Theses scanned by UMI/ProQuest. |
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