Yes / Electron‐deficient half‐sandwich complexes are a class of under‐studied organometallics with demonstrated potential as metallodrug candidates. The present study investigates the effect of two 16‐electron organoruthenium complexes ([( p‐ cym)Ru(benzene‐1,2‐dithiolato)] ( 1 ) and [( p ‐cym)Ru(maleonitriledithiolate)] ( 2 )) on the cell viability of non‐immortalised human lymphocytes from healthy individuals. The genotoxic effects of 1 and 2 in lymphocytes using the Comet and cytokinesis‐block micronucleus assays is also investigated. Gene expression studies were carried out on a panel of genes involved in apoptosis and DNA damage repair response. Results show that the two 16‐electron complexes do not have significant effect on the cell viability of human lymphocytes from healthy individuals. However, an increase in DNA damage is induced by both compounds, presumably through oxidative stress production. / This project was supported by the Royal Society (University Research Fellowship No. UF150295 to NPEB), the University of Bradford (RDF Award), and by the Academy of Medical Sciences/the Wellcome Trust/ the Government Department of Business, Energy and Industrial Strategy/ the British Heart Foundation Springboard Award [SBF003\1170 to NPEB].
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18162 |
| Date | 29 October 2020 |
| Creators | Habas, Khaled S.A., Soldevila Barreda, Joan J., Azmanova, Maria, Rafols, Laia, Pitto-Barry, Anaïs, Anderson, Diana, Barry, Nicolas P.E. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2020 Wiley‐VCH GmbH. This is the peer reviewed version of the following article: Habas K, Soldevila Barreda JJ, Azmanova M et al (2020) Evaluation of the toxicity of two electron-deficient half-sandwich complexes against human lymphocytes from healthy individuals. ChemMedChem. 16(4): 624-629, which has been published in final form at https://doi.org/10.1002/cmdc.202000672. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
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