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Synthesis, photophysical and biological studies of lanthanide complexes for photodynamic therapy

1.2\xPrior to the PDT, we have also synthesized a series of water-soluble homoleptic lanthanides (Ln3+ = Gd, Er, and Yb) sandwich (DD) di-PEGylated porphyrin complexes. The Yb complex (YbDD) has shown the same NIR emission quantum yield as the highest record Yb complex in the literature (Yb-RhB), yet, the emission intensity is double compared to the Yb-N. This implies a new thinking about the quantity measurement for biological imaging. The brightness might be the prime factor for the development of luminescence in vitro/in vivo imaging agent rather than the emission quantum yield.

Identiferoai:union.ndltd.org:hkbu.edu.hk/oai:repository.hkbu.edu.hk:etd_oa-1467
Date14 September 2017
CreatorsZhou, Yan
PublisherHKBU Institutional Repository
Source SetsHong Kong Baptist University
LanguageEnglish
Detected LanguageEnglish
Typetext
Formatapplication/pdf
SourceOpen Access Theses and Dissertations

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