Phospholipase C mediated hydrolysis of the phosphoinositides yields second messenger products which have been linked to normal and abnormal cell growth processes. It has been suggested that fatty acids may regulate phospholipase C activity in vivo. This study sought to investigate relationships between phospholipase C activity, tumor size and dietary linoleic and stearic acids.Phospholipase C activity, of livers and serially transplanted mammary adenocarcinomas from female strain A/ST mice on one of three diets, was measured. Tumors ranged from .20 to 2.98 g at the time of removal. Phospholipase C activity of tumors was negatively and significantly (p<.Ol) correlated to increasing tumor weight in those diet groups that contained linoleic acid and no added stearic acid. The highest PLC activity was seen in small tumors across all diet groups. Maximum PLC activity of tumors was over 2 fold higher than the maximum activity of livers across all diet groups. PLC activity of the liver was negatively and significantly (p<.02) correlated to increasing tumor weight for samples from the high linoleic acid diet (SF-15). This research concludes that PLC activity varies during tumorigenesis and may reflect tumor development. / Department of Biology
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/184140 |
| Date | January 1991 |
| Creators | Shaffer, Lauren A. |
| Contributors | Ball State University. Dept. of Biology., Bennett, Alice S. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | v, 56 leaves : ill. ; 28 cm. |
| Source | Virtual Press |
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