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A Study of the prognostic value of B[beta]2 microglobulin in nasopharyngeal carcinoma.

by Hiu Wong. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1991. / Includes bibliographical references. / SUMMARY --- p.1 / INTRODUCTION --- p.4 / LITERATURE REVIEW --- p.8 / Chapter I. --- Nasopharyngeal carcinoma (NPC) --- p.8 / Chapter A. --- Epidemiology of NPC --- p.8 / Chapter B. --- Anatomy of NPC --- p.11 / Chapter C. --- Pathology of NPC --- p.12 / Chapter D. --- Histological classification of NPC --- p.14 / Chapter E. --- Stage classification of NPC --- p.15 / Chapter F. --- Clinical feature of NPC --- p.18 / Chapter G. --- Diagnosis of NPC --- p.19 / Chapter (a) --- Clinical examination / Chapter (b) --- Radiographic examination / Chapter (c) --- Laboratory examination / Chapter (d) --- Biopsy examination / Chapter H. --- Treatment of NPC --- p.21 / Chapter (a) --- Surgery / Chapter (b) --- Chemotherapy / Chapter (c) --- Radiotherapy / Chapter I. --- Prognosis of NPC --- p.23 / Chapter J. --- Etiology of NPC --- p.24 / Chapter (a) --- Dietary factor / Chapter (b) --- Genetic factor / Chapter (c) --- Environmental factor / Chapter (d) --- EBV infection / Chapter (e) --- Others / Chapter II. --- Beta-2 Microglobulin (B2M) --- p.30 / Chapter A. --- Structure and function of B2M --- p.30 / Chapter B. --- Clinical chemistry of B2M --- p.33 / Chapter C. --- B2M and its relationship to immunogenetic system --- p.34 / Chapter D. --- B2M in solid malignancies --- p.35 / Chapter E. --- B2M in hematologic malignancies --- p.36 / Chapter F. --- B2M in non-malignant diseases --- p.38 / Chapter III. --- Epstein - Barr Virus (EBV) --- p.41 / Chapter A. --- Morphology / Chapter B. --- EBV infection --- p.42 / Chapter C. --- EBV and Nasopharyngeal Carcinoma --- p.44 / Chapter D. --- Relationship of EBV to other human disease --- p.46 / Chapter (a) --- The relationship of EBV to IM / Chapter (b) --- The relationship of EBV to BL / Chapter E. --- EBV genome-carrying lymphoid cell lines --- p.50 / Chapter IV. --- TUMOUR ANTIGEN OF SQUEMOUS CELL CARCINOMA --- p.55 / Chapter A. --- The source of TA-4 --- p.55 / Chapter B. --- Characteristics of TA-4 --- p.56 / Chapter C. --- TA-4 in squamous cell carcinoma of uterine cervix --- p.57 / Chapter D. --- TA-4 in other type of squamous cell carcinaoma --- p.58 / MATERIALS AND METHODS / Chapter A. --- Materials --- p.61 / Chapter B. --- Measurement of Beta-2 Microglobulin --- p.63 / Chapter (a) --- Principles / Chapter (b) --- Assay protocol / Chapter (c) --- Reproducibility / Chapter C. --- Detection of EBV antibody titres in human sera --- p.68 / Chapter (a) --- Induction of EA/VCA in Raji/P3HR-1 cell lines / Chapter (b) --- Detection of antibody titres to EA/VCA in human sera / Chapter D. --- Measurement of squamous cell carcinoma associated antigen --- p.75 / RESULTS --- p.79 / Chapter A. --- Diurnal change of serum B2M or TA-4 level --- p.79 / Chapter B. --- The B2M and TA-4 levels in apparently healthy people --- p.81 / Chapter C. --- The usefullness of assay in initial diagnosis and staging --- p.81 / Chapter (a) --- Correlation between serum B2M levels and staging of NPC / Chapter (b) --- Correlation between serum TA-4 levels and staging of NPC / Chapter D. --- Correlation between histological differentiation of NPC and B2M and TA-4 level --- p.91 / Chapter E. --- The usefulness of assay for monitoring the NPC --- p.93 / Chapter (a) --- patients achieved completed remission / Chapter (b) --- patients developed local recurrence / Chapter (c) --- patients developed distant metastases / DISCUSSION --- p.131 / Chapter A. --- Serum B2M in NPC patients --- p.131 / Chapter B. --- Serum TA-4 in NPC ptients --- p.136 / Chapter C. --- EBV antibody titres in NPC patients --- p.137 / Chapter D. --- Conclusion --- p.141 / Chapter E. --- Suggested further study --- p.143 / REFERENCES --- p.146

Identiferoai:union.ndltd.org:cuhk.edu.hk/oai:cuhk-dr:cuhk_318823
Date January 1991
ContributorsWong, Hiu., Chinese University of Hong Kong Graduate School. Division of Clinical and Pathological Sciences.
PublisherChinese University of Hong Kong
Source SetsThe Chinese University of Hong Kong
LanguageEnglish
Detected LanguageEnglish
TypeText, bibliography
Formatprint, [v], 169 leaves : ill. ; 30 cm.
RightsUse of this resource is governed by the terms and conditions of the Creative Commons “Attribution-NonCommercial-NoDerivatives 4.0 International” License (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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