Alzheimer’s disease (AD) progression and hypotheses of the cognitive reserve
theory were investigated by testing for a relation between educational attainment and
rate of decline in patients with Mild Cognitive Impairment, possible AD, probable AD,
and other progressive neurodegenerative dementias. Patient data (n = 726) were
acquired from a clinical database at the Minneapolis VAMC GRECC Memory Loss
Clinic. Analyses using mixed effect regression models found education was
significantly related to an accelerated rate of decline in global cognition (MMSE:
-0.022, SE = 0.007, p = .003) and a steeper linear rate of decline in functional ability
(Cognitive Performance Test: -0.034, SE = 0.011, p = .005). Cox proportional hazard
models found little evidence to support an association between educational attainment
and relative mortality risk. These results are consistent with previous findings and
predictions of the cognitive reserve theory.
| Identifer | oai:union.ndltd.org:tamu.edu/oai:repository.tamu.edu:1969.1/ETD-TAMU-1189 |
| Date | 15 May 2009 |
| Creators | Hemmy, Laura Sue |
| Contributors | Snyder, Douglas K. |
| Source Sets | Texas A and M University |
| Language | en_US |
| Detected Language | English |
| Type | Book, Thesis, Electronic Dissertation, text |
| Format | electronic, application/pdf, born digital |
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