Advances in the field of medicine have extended the average human life expectancy worldwide. As a result an increasing number of people will suffer from problems associated with their mineralized tissues and will require orthopedic and dental implants to restore their quality of life. Ideally, implants should have mechanical and structural properties compatible with the original mineralized tissue, and should also promote faster and stronger implant fixation. An improved understanding of the properties of mineralized tissues can help with the improvements of implants. This thesis focuses on improving the understanding of two aspects related to mineralized tissues and implant systems: the mechanical properties of peri-implant bone, and the mechanical, composition and structural properties of dentin and jawbone.
Studies have shown that local delivery of alendronate, an anti-osteoporosis drug, enhances new bone formation; however, the effects of the drug on the elastic modulus of new formed bone are unknown. In this study, nanoindentation was used to evaluate and compare the elastic modulus of peri-implant bone with and without the presence of alendronate. To better understand the properties of dentin and jawbone, nanoindentation and qualitative backscattered electron imaging were used to measure their elastic modulus, mineral content and volume fraction, and regression analyses were used to establish correlation between the properties.
In this thesis, mineralized tissue samples were collected from an animal study. To study the effects of alendronate on the elastic modulus of peri-implant bone, porous tantalum implants with three different coating treatments were used: non-coated (Ta), calcium phosphate coated (Ta-CaP), alendronate-immobilized-calcium-phosphate coated (Ta-CaP-ALN). The calcium phosphate coatings, with or without alendronate, increased the elastic modulus of peri-implant Ingrown Bone by approximately 22% (3GPa). The addition of alendronate did not significantly increase the elastic modulus of peri-implant.
For the study of dentin and jawbone, regression analyses showed that the elastic modulus of dentin is strongly dependent on the porosity and to a lesser extent on the calcium content. The elastic modulus of jawbone and dentin were compared and the elasticmodulus of jawbone was generally higher than that of dentin while the mineral content was lower.
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:BVAU./2648 |
| Date | 05 1900 |
| Creators | Tang, Allen |
| Publisher | University of British Columbia |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | 4931427 bytes, application/pdf |
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