Loss-of-function mutations causing haploinsufficiency of the MC4R are the most common monogenic cause of severe early-onset obesity in humans. Research has primarily focused on how central MC4R contributes to energy homeostasis with the eventual goal of developing anti-obesity therapeutics. MC4R expression has been found in vago-vagal circuitry, as well as in enteroendocrine cell populations in the gastrointestinal tract. Multi-choice feeding studies in MC4R deficient mice revealed a surprising reduction in preference for palatable foods high in either fats or carbohydrates. This loss of macronutrient preference was also coupled with a homeostatic drive for hyperphagia. These complex defects in feeding behaviors were suggestive of defects in the gut-brain axis, a cascade of neural and hormonal signals which bi-directionally control feeding behaviors. Gastrointestinal expression of MC4R in L cells was shown to be functionally significant as MC4R agonism stimulated peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) secretion in vivo. These findings highlighted a complementary role for peripheral MC4R in the gut-brain axis that has implications for energy and glucose homeostasis. Furthermore, pharmacological action of melanocortin compounds at peripheral sites must now be considered when examining effects of the receptor on whole-animal physiology.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-07162014-230748 |
| Date | 25 July 2014 |
| Creators | Panaro, Brandon Lee |
| Contributors | Danny Winder, Ph.D., Alyssa Hasty, Ph.D., Aurelio Galli, Ph.D., Louis Muglia, M.D., Ph.D., Mentor: Roger Cone, Ph.D. |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-07162014-230748/ |
| Rights | restrictsix, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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