We hypothesized that the presence of monoclonal free light chains (FLC) in the serum of patients with monoclonal gammopathy of undetermined significance (MGUS) is a marker of clonal evolution and a risk factor for progression. Forty-seven patients with MGUS and documented progression to myeloma or related malignancy were compared with 50 age- and gender-matched patients with MGUS and no evidence of progression after 5 or more years of follow-up. The presence of an abnormal kappa/lambda FLC ratio in the serum was associated with a higher risk of MGUS progression (relative risk 2.5; 95% confidence interval: 1.6-4.0; P < 0.001).
| Identifer | oai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-19908 |
| Date | 01 November 2004 |
| Creators | Rajkumar, S. Vincent, Kyle, Robert A., Therneau, Terry M., Clark, Raynell J., Bradwell, Arthur R., Melton, L. Joseph, Larson, Dirk R., Plevak, Matthew F., Katzmann, Jerry |
| Publisher | Digital Commons @ East Tennessee State University |
| Source Sets | East Tennessee State University |
| Detected Language | English |
| Type | text |
| Source | ETSU Faculty Works |
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