Magister Pharmaceuticae - Mpharm / Many studies have investigated the pharmacokinetics (PK) of anti-tuberculosis drugs
in tuberculosis patients. However, currently in South Africa, no studies have been
done on ethionamide (ETH) PK in adult MDR-TB patients that are infected with HIV
and those without HIV infection. Therefore, the objective of this current study was
firstly, to find out ethionamide plasma concentration using the LC-MS method;
secondly, to evaluate and compare the pharmacokinetics of ethionamide in MDR-TB
patients infected with and without HIV infection; thirdly, to examine the effects of
ARVs and kidney impairment on the PK of ethionamide and fourthly, to find out the
consequence of sex and age on ETH PK parameters.
| Identifer | oai:union.ndltd.org:netd.ac.za/oai:union.ndltd.org:uwc/oai:etd.uwc.ac.za:11394/6186 |
| Date | January 2017 |
| Creators | Ezeukwu, Ifeoma Patricia |
| Contributors | Mugabo, Pierre |
| Publisher | University of the Western Cape |
| Source Sets | South African National ETD Portal |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Rights | University of the Western Cape |
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