The biosensing field has grown in importance and research efforts over the last few years for many reasons including point of care sensing devices and possible early detection of diseases in the body. Dopamine sensing is discussed in this paper and the development of a dopamine sensing platform would lead to early detection of diseases linked to its abundance or lack thereof in the brain such as Parkinson's disease. This work focuses on the electrochemical methods of biosensing, specifically dopamine sensing, and this method involves the use of electrodes as its sensing component. Multimaterial electrode-embedded fibers are used as the sensing electrode and the electrode material presented is platinum (Pt). Platinum is employed because of its biocompatibility property. The electrodes are placed in the fiber by the method of convergence fiber drawing and the fiber ends are stripped to expose the electrode for application. To make the proposed sensing platform more cost-effective, the platinum is electrodeposited onto the multimaterial fiber's embedded electrode. We discuss the use of a W/Pt modified electrode and a pure platinum wire in dopamine sensing and demonstrate that Pt is indeed a good candidate for dopamine sensing. The results show that the sensitivity of the W/Pt modified electrode to dopamine is higher than that of a pure Pt wire. This work has shown the promising application of electrodeposition in developing a cheaper flexible biosensing platform and opens up the possibility of the development of wearable flexible smart textile sensors because of the use of flexible multimaterial fibers. / Master of Science / The idea of sensing is important to our world and various scientific developments in this area have improved our way of life as humans. Biological sensing, which is what this thesis focuses on, detects the presence of various substances in the body, and developments in the area of biosensing have led to the creation of devices that can detect diseases or gather general information about a person's anatomical state. There has been increased interest in the detection of dopamine as more studies show that some diseases such as Parkinson's disease are related to the amounts of dopamine present in the brain. In this work, we present a potential platform for sensing dopamine in vitro using electrochemistry. Multimaterial fibers with embedded electrodes capable of measuring dopamine were fabricated using a thermal drawing technique. The electrode material in this fiber is the most important part of the sensing platform as it is what determines how sensitive the fiber is to an analyte. The two main topics discussed in this work are the modification of the electrode material using an electrodeposition technique and the sensing of dopamine with the modified electrode using the electrochemical methods of cyclic voltammetry and differential pulse voltammetry. The material involved in the electrodeposition process is Platinum (Pt) and the results show that platinum is a suitable material for dopamine sensing.
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/112992 |
| Date | 30 June 2021 |
| Creators | Alabi, Oluwademilade Adedunmolu |
| Contributors | Electrical Engineering, Jia, Xiaoting, Zhou, Wei, Zhu, Yizheng |
| Publisher | Virginia Tech |
| Source Sets | Virginia Tech Theses and Dissertation |
| Detected Language | English |
| Type | Thesis |
| Format | ETD, application/pdf |
| Rights | In Copyright, http://rightsstatements.org/vocab/InC/1.0/ |
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