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Neuroregulation and Myosin Light Chain Phosphorylation in Ascaris Suum Obliquely Striated Skeletal Muscle

Extraction and quantitation of myosin light chain two coupled with myograph recordings from Ascaris muscle perfused with calmodulin inhibitors and neurotransmitters in conjunction with their respective agonists and antagonists have been used to establish the regulation of contraction in this muscle. Densitometric tracings of isolectric focusing gels separating the regulatory light chain were used to quantitate phosphorylation in resting, contracted and flaccid muscle. These studies indicated that inhibitory neurostimulation is mediated by a true GABA receptor. Myosin-mediated contraction is responsible for maintaining the level of tension observed in resting actin-mediated muscle. Actin-mediated contraction is responsible for the rapid rise in tension following excitatory stimuli. Both systems function simultaneously and are independant.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc504635
Date08 1900
CreatorsMartin, Rex E. (Rex Edward)
ContributorsDonahue, Manus J., Schafer, Rollie, Masaracchia, Ruthann A.
PublisherNorth Texas State University
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatvii, 81 leaves : ill., Text
RightsPublic, Martin, Rex E. (Rex Edward), Copyright, Copyright is held by the author, unless otherwise noted. All rights reserved.

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