We have previously shown that non-specific blockade of the cyclooxygenase (COX) enzymes in skeletal muscle eliminates the normal increase in muscle protein synthesis following resistance exercise. The current study tested the hypothesis that this COX-mediated increase in postexercise muscle protein synthesis is specifically regulated by the COX-2 isoform. Sixteen males (23 ± 1 yr, 177 ± 2 cm, 81.5 ± 3.4 kg) were randomly assigned to one of two groups that received three doses of either a specific COX-2 inhibitor (celecoxib; 200 mg per dose, 600 mg total) or a placebo during the 24 hours following a single bout of resistance exercise with the knee extensors. Skeletal muscle fractional synthesis rate (FSR) was measured at rest and 24 hours postexercise using a primed constant infusion of [2H5]phenylalanine coupled with muscle biopsies of the vastus lateralis. Mixed muscle FSR was increased following exercise to a greater extent (206%, P<0.05) in the COX-2 group (0.052 ± 0.014 %Ih) as compared with the placebo group (0.017 ± 0.007 %Ih). These results suggest that the specific inhibition of the COX-2 isoform in human skeletal muscle causes a compensatory response in muscle protein synthesis. These data also highlight the involvement of the cyclooxygenase pathways in the regulation of muscle protein synthesis following resistance exercise. / School of Physical Education, Sport, and Exercise Science
| Identifer | oai:union.ndltd.org:BSU/oai:cardinalscholar.bsu.edu:handle/188272 |
| Date | January 2007 |
| Creators | Burd, Nicholas A. |
| Contributors | Trappe, Todd A. |
| Source Sets | Ball State University |
| Detected Language | English |
| Format | vii, 114 leaves : ill. (some col.) ; 28 cm. |
| Source | Virtual Press |
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