<p>Different mutations within the <em>NALP3</em> gene are thought to be associated with development of several types of hereditary auto inflammatory disorders such as neonatal onset multisystem inflammatory disorder (NOMID) and muckle-wells syndrome (MWS). In this work two separate mutations E688K and G569R were supposed to be constructed by site-directed mutagenesis in the cloned wild type <em>NALP3</em> genes and further expressed in bacterial and mammalian host cells for functional studies in protein -protein interaction models.</p>
| Identifer | oai:union.ndltd.org:UPSALLA/oai:DiVA.org:his-4246 |
| Date | January 2009 |
| Creators | Fetah, Alija |
| Publisher | University of Skövde, School of Life Sciences |
| Source Sets | DiVA Archive at Upsalla University |
| Language | English |
| Detected Language | English |
| Type | Student thesis, text |
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