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Endocannabinoid System in a Planarian Model

In this study, the presence and possible function of endocannabinoid ligands in the planarian is investigated. The endocannabinoids ananadamide (AEA) and 2-arachidonoylglycerol (2-AG) and entourage NAE compounds palmitoylethanolamide (PEA), stearoylethanolamide (SEA) and oleoylethanolamide (OEA) were found in Dugesia dorotocephala. Changes in SEA, PEA, and AEA levels were observed over the initial twelve hours of active regeneration. Exogenously applied AEA, 2-AG and their catabolic inhibition effected biphasic changes in locomotor velocity, analogous to those observed in murines. The genome of a close relative, Schmidtea mediterranea, courtesy of the University of Utah S. med genome database, was explored for cannabinoid receptors, none were found. A putative fatty acid amide hydrolase (FAAH) homolog was found in Schmidtea mediterranea.

Identiferoai:union.ndltd.org:unt.edu/info:ark/67531/metadc33188
Date12 1900
CreatorsMustonen, Katie Lynn
ContributorsVenables, Barney J., Chapman, Kent D., Roberts, Aaron P.
PublisherUniversity of North Texas
Source SetsUniversity of North Texas
LanguageEnglish
Detected LanguageEnglish
TypeThesis or Dissertation
Formatix, 138 p.: ill., Text
RightsPublic, Copyright, Mustonen, Katie Lynn, Copyright is held by the author, unless otherwise noted. All rights reserved.

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