Calcium ions (Ca2+) are admitted into presynaptic nerve terminals through voltage gated calcium channels and diffuse to bind and activate the secretory vesicle discharge
mechanism. Current research favors a highly ‘modal’ organization where the release
sites are activated by one or a few closely apposed channels (Stanley, 1997). To fully
understand the nanophysiology of transmitter release site activation, it is necessary to
determine the rate of Ca2+ flux through individual channels at normal physiological
external concentrations. OBJECTIVE: To explore the relationship between CaV2.2
channel conductance and external Ca2+ across the physiological range. CONCLUSION:
The conductance of the CaV2.2 channel was determined across the range of 1-100 mM
[Ca2+]EXT . With 2 mM [Ca2+]EXT, the conductance was determined to be 2.76 ± 0.24 pS.
| Identifer | oai:union.ndltd.org:TORONTO/oai:tspace.library.utoronto.ca:1807/18991 |
| Date | 17 February 2010 |
| Creators | Weber, Alexander M. |
| Contributors | Stanley, Elise F. |
| Source Sets | University of Toronto |
| Language | en_ca |
| Detected Language | English |
| Type | Thesis |
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