The hippocampus is necessary for normal memory in rodents, birds, monkeys, and people. Damage to the hippocampus can result in the inability to learn new facts, defined by the relationship among stimuli. In rodents, spatial learning involves learning about the relationships among stimuli, and exemplifies the kind of learning the requires the hippocampus. Therefore, understanding the neural mechanisms underlying spatial learning may elucidate basic memory processes. Many hippocampal neurons fire when behaving rats, cats, or monkeys are in circumscribed regions (place fields) of an environment. The neurons, called place cells, fire in relation to distal stimuli, but can persist in signaling location when the stimuli are removed or lights are turned off (memory fields). In this thesis, computational models of spatial information processing simulated many of the defining properties of hippocampal place cells, including memory fields. Furthermore, the models suggested a neurally plausible mechanism of goal directed spatial navigation which involved the encoding of distances in the connections between place cells. To navigate using memory fields, the models required an excitatory, distributed, and plastic association system among place cells. Such properties are well characterized in area CA3 of the hippocampus. In this thesis, a new electrophysiological study provides evidence that a second system in the dentate gyrus has similar properties. Thus, two circuits in the hippocampus meet the requirements of the models. Some predictions of the models were then tested in a single-unit recording experiment in behaving rats. Place fields were more likely to occur in information rich areas of the environment, and removal of single cues altered place fields in a way consistent with the distance encoding mechanism suggested by the models. It was concluded that a distance encoding theory of rat spatial navigation has much descriptive and predictive utility, but most of its predic
| Identifer | oai:union.ndltd.org:LACETR/oai:collectionscanada.gc.ca:QMM.28778 |
| Date | January 1995 |
| Creators | Hetherington, Phil A. (Phillip Alan) |
| Contributors | Shapiro, Matthew L. (advisor) |
| Publisher | McGill University |
| Source Sets | Library and Archives Canada ETDs Repository / Centre d'archives des thèses électroniques de Bibliothèque et Archives Canada |
| Language | English |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Format | application/pdf |
| Coverage | Doctor of Philosophy (Department of Psychology.) |
| Rights | All items in eScholarship@McGill are protected by copyright with all rights reserved unless otherwise indicated. |
| Relation | alephsysno: 001447480, proquestno: NN05721, Theses scanned by UMI/ProQuest. |
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