The central nervous system shows sexual dimorphism in the structure and functions in vertebrates. Brain sexual differentiation is resulted from the neural development. The neural development of the brain is influenced by the genetic factors and the external environmental factors. Serotonin (5-HT) functions as a differentiation signal in the early developing period. There are seven 5-HT receptors (5-HT1¡B5-HT2¡B5-HT3¡B5-HT4¡B5-HT5¡B5-HT6¡B5-HT7 receptor) . The 5-HT cell is one of the earliest differentiated neurons in the brain. In the present study, the role of central 5-HT system for the temperature-related neural development was investigated. These results showed that the proliferation of neurons was enhanced by 5-HT. The elevated temperature-induced proliferation of 5-HT cell might be mediated by the 5-HT receptor 1A type. On the other hand, estrogen receptor £\ (ER£\) is involved in the estrogen-enhanced proliferation of 5-HT cell in the neural culture. The ER£\ antagonist suppressed the elevated temperature-induced proliferation of 5-HT cell. It is suggested that the ER£\ plays a role in the mechanism of high temperature-induced the proliferation of 5-HT cell.
| Identifer | oai:union.ndltd.org:NSYSU/oai:NSYSU:etd-0712105-152328 |
| Date | 12 July 2005 |
| Creators | Huang, Shi-fei |
| Contributors | Yi-ming Chue, Ching-lin Tsai, Ray-tong Chang |
| Publisher | NSYSU |
| Source Sets | NSYSU Electronic Thesis and Dissertation Archive |
| Language | Cholon |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.lib.nsysu.edu.tw/ETD-db/ETD-search/view_etd?URN=etd-0712105-152328 |
| Rights | not_available, Copyright information available at source archive |
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