Yes / We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a
highly hydrophobic organometallic arene ruthenium dithiolatoecarborane complex [Ru(p-cymene) (1,2-
dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer
P123 coreeshell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation,
towards human ovarian cancer cells (A2780; IC50 0.14 mM and 0.17 mM, respectively) and cisplatinresistant
human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 mM, respectively). Complex 1 was
particularly sensitive to neutron irradiation in A2780cisR cells (2.6 more potent after irradiation
compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles
resulted in higher cellular accumulation (2.5 ), and was sensitive to neutron irradiation in A2780 cells
(1.4 more potent upon irradiation compared to non-irradiation). / We thank the Leverhulme Trust (Early Career Fellowship No. ECF-2013-414 to NPEB), the University of Warwick (Grant No. RD14102 to NPEB), the University of Birmingham/EPSRC Follow-on- Fund (Grant No UOBFOF026 to BP), the ERC (Grant No. 247450 to PJS), EPSRC (EP/F034210/1 to PJS).
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11232 |
| Date | 18 May 2015 |
| Creators | Romero-Canelón, I., Phoenix, B., Pitto-Barry, Anaïs, Tran, J., Soldevila-Barreda, Joan J., Kirby, N., Green, S., Sadler, P.J., Barry, Nicolas P.E. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/ )., CC-BY |
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