Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors?

Description

No / In the November issue (2001) of Neuroscience Letters, Holmin et al. (Neurosci. Lett. 314 (2001) 151) reported that the synthesis of the intermediate filament protein nestin was upregulated by potassium-induced depolarization in the rat cortex. In this letter, we provide supplementary evidence that repeated cortical spreading depression elicited by potassium induces a delayed upregulation of nestin. However, we argue against the authors' conclusion, Nestin expression was N-methyl-D-aspartate (NMDA)-receptor dependent since dizocilpine (MK-801) treatment abolished the response because spreading depression itself is very sensitive to NMDA-receptor block, and the drug treatment was initiated prior to potassium application to the cortex in Holmin et al.'s study.

Links & Downloads

1. Obrenovitch, T.P., Chazot, P.L. and Godukhin, O.V. (2002). Repetitive spreading depression induces nestin protein expression in the cortex of rats and mice. Is this upregulation initiated by N-methyl-D-aspartate receptors? Neuroscience Letters. Vol. 320, No. 3, pp. 161-163.
2. http://hdl.handle.net/10454/3115
3. https://doi.org/10.1016/S0304-3940(02)00046-0

Tags

Neuroglia

Central nervous system

Brain vertebrata

Mammalia

Rodentia

Rat

Mouse

Gene expression

Astrocyte

NMDA receptor

Cerebral cortex

Spreading depression

Additional Fields

Identifer	oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/3115
Date	January 2002
Creators	Obrenovitch, Tihomir P., Chazot, P.L., Godukhin, O.V.
Source Sets	Bradford Scholars
Language	English
Detected Language	English
Type	Article, No full-text in the repository