Return to search

Regulation of Synapse Development by Activity Dependent Transcription in Inhibitory Neurons

Neuronal activity and subsequent calcium influx activates a signaling cascade that causes transcription factors in the nucleus to rapidly induce an early-response program of gene expression. This early-response program is composed of transcriptional regulators that in turn induce transcription of late-response genes, which are enriched for regulators of synaptic development and plasticity that act locally at the synapse.

Identiferoai:union.ndltd.org:harvard.edu/oai:dash.harvard.edu:1/11151534
Date07 June 2014
CreatorsMardinly, Alan Robert
ContributorsGreenberg, Michael Eldon
PublisherHarvard University
Source SetsHarvard University
Languageen_US
Detected LanguageEnglish
TypeThesis or Dissertation
Rightsopen

Page generated in 0.0019 seconds