Yes / Antibacterial hydrogels have been intensively
studied due to their wide practical potential in wound healing.
However, developing an antibacterial hydrogel that is able to
integrate with exceptional mechanical properties, cell affinity, and
adhesiveness will remain a major challenge. Herein, a novel
hydrogel with antibacterial and superior biocompatibility properties was developed using aluminum ions (Al3+) and alginate−
dopamine (Alg-DA) chains to cross-link with the copolymer chains
of acrylamide and acrylic acid (PAM) via triple dynamic
noncovalent interactions, including coordination, electrostatic
interaction, and hydrogen bonding. The cationized nanofibrillated
cellulose (CATNFC), which was synthesized by the grafting of
long-chain quaternary ammonium salts onto nanofibrillated
cellulose (NFC), was utilized innovatively in the preparation of antibacterial hydrogels. Meanwhile, alginate-modified dopamine
(Alg-DA) was prepared from dopamine (DA) and alginate. Within the hydrogel, the catechol groups of Alg-DA provided a decent
fibroblast cell adhesion to the hydrogel. Additionally, the multitype cross-linking structure within the hydrogel rendered the
outstanding mechanical properties, self-healing ability, and recycling in pollution-free ways. The antibacterial test in vitro, cell
affinity, and wound healing proved that the as-prepared hydrogel was a potential material with all-around performances in both
preventing bacterial infection and promoting tissue regeneration during wound healing processes. / This work was supported by the National Natural Science Foundation of China (32070826 and 51861165203), the Chinese Postdoctoral Science Foundation (2019M650239, 2020T130762), the Sichuan Science and Technology Program (2019YJ0125), the State Key Laboratory of Polymer Materials Engineering (sklpme2019-2-19), the Chongqing Research Program of Basic Research and Frontier Technology (cstc2018jcyjAX0807), Chongqing Medical Joint Research Project of Chongqing Science and Technology Committee & Health Agency (2020GDRC017), and the RCUK China-UK Science Bridges Program through the Medical Research Council, and the Fundamental Research Funds for the Central Universities.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18387 |
| Date | 22 February 2021 |
| Creators | Deng, X., Huang, B., Wang, Q., Wu, W., Coates, Philip D., Sefat, Farshid, Lu, C., Zhang, W., Zhang, X. |
| Publisher | ACS PUBLICATION |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Accepted manuscript |
| Rights | © 2020 ACS. This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry and Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssuschemeng.0c06672. |
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