v
It was found that most of the classical scrapie genotypes belong to R3 risk group,
whereas atypical scrapie genotypes belonging to zero (0) and one (1) risk groups were
frequently seen in sheep analyzed. In other words, Turkish sheep is found to have
intermediate risk of classical scrapie and low atypical scrapie risk, in general.
The data from the current study may help to establish a breeding program for classical
scrapie control in Turkey and will be beneficial for both the animal and public health in
the country. In addition, the outcomes of the study will fill the gap which is present in
the geographic distribution data of PrP gene polymorphisms in Eurasia.Scrapie is an infectious fatal disease of sheep and goats which affects the central nervous
system. In the present study, samples of 14 native Turkish sheep breeds (n=655) were
analyzed with respect to their polymorphisms of PrP gene (at codons: 136, 141, 154 and
171) and their classical and atypical scrapie risk levels were identified.
Turkish sheep are found to have the highest PrP genetic variability with 13 classical
scrapie alleles and 14 atypical scrapie alleles compared to all previous studies. Classical
scrapie-susceptible and wild-type ARQ allele was found as the most frequent allele in
Turkish sheep examined. The most classical scrapie-susceptible allele, VRQ was
detected at low frequencies in 5 of the breeds (Ç / ine Ç / apari, Dagliç / , Kivircik, Karayaka
and Gö / kç / eada). One novel allele (TL141HQ) was observed in Sakiz breed for the first
time in this study.
| Identifer | oai:union.ndltd.org:METU/oai:etd.lib.metu.edu.tr:http://etd.lib.metu.edu.tr/upload/12614353/index.pdf |
| Date | 01 June 2012 |
| Creators | Uzun, Begum |
| Contributors | Togan, Inci |
| Publisher | METU |
| Source Sets | Middle East Technical Univ. |
| Language | English |
| Detected Language | English |
| Type | M.S. Thesis |
| Format | text/pdf |
| Rights | Access forbidden for 1 year |
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