The following dissertation herein discusses the role of axonal protein synthesis in Aβ1-42-dependent neurodegeneration, which has important implications in AD pathogenesis. In Part 1, I provide a brief introduction to relevant topics including neurodegeneration and axonal protein synthesis. In Part 2, I discuss findings that we published in 2014 describing a mechanism by which axonal exposure to Aβ1-42 induces cell death via axonal synthesis and retrograde transport of a transcription factor, ATF4. In Part 3, I discuss a follow-up project that I conducted independently, which is not yet published but is in preparation for submission describing the immediate effect of Aβ1-42 on axonal protein synthesis, which mediates the downstream axonal ATF4 signaling events described in Part 2. In Part 4, I discuss the key findings from these two projects including their significance and potential future directions. In the Appendix, I provide details regarding experimental methods and statistical analyses performed in Part 3.
| Identifer | oai:union.ndltd.org:columbia.edu/oai:academiccommons.columbia.edu:10.7916/D89P3D18 |
| Date | January 2017 |
| Creators | Walker, Chandler |
| Source Sets | Columbia University |
| Language | English |
| Detected Language | English |
| Type | Theses |
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