Migraines are one of the most disabling neurovascular disorders of which there is still no exact etiology. Most of the studies concerning the pathophysiology of migraines revolve around the notion that the key players are meningeal vascular mechanisms working in conjunction with local trigeminal afferents. Cortical spreading depression, the Trigeminovascular system, and the Blood-Brain-Barrier are other potential contributors but need further investigation. This literature thesis will explore the relationship between the vasculature and neurological mechanisms in the initiation of migraine episodes and provide a plausible mechanism that combines current evidence provided by the literature.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/42149 |
| Date | 21 February 2021 |
| Creators | Garcia, Jr., Alfonso Antonio R. |
| Contributors | Gong, Haiyan |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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