Information is processed in the mammalian cortex through both long-range and local circuits. Our understanding of how neurons in cortical circuits are arranged to process and route these sensory, motor, associative signals during behavior is limited. Here, \textit{in vivo} labelling and recording of projection neurons between primary and secondary mouse somatosensory cortex (S1 and S2) revealed shared and distinct information transfer between areas during a during context-dependent sensory processing task. Development and application of the novel CRACK platform to link the function and transcriptomic identity of hundreds of cells simultaneously revealed specific roles for molecular cell types within S1. The sensory-driven excitatory cell type Baz1a was found to maintain stimulus responsiveness during altered sensory experience and showed increased anatomical connectivity to somatostatin-expressing cells. This suggests Baz1a cells are situated to bias S1 towards bottom-up sensory inputs, answering a mechanistic question as to how the cortex can negotiate between feedforward and feedback input based on need. Together, these findings enhance our understanding of the cellular components and their roles in S1.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/43703 |
| Date | 26 January 2022 |
| Creators | Condylis, Cameron |
| Contributors | Chen, Jerry L. |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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