Liraglutide, a Glucagon-Like Peptide 1 (GLP-1) receptor agonist, is used as a treatment for Type 2 Diabetes Mellitus (T2DM) and
obesity because it improves glycemia and decreases food intake. Here, we tested whether chronic activation of the GLP-1 receptor system
with liraglutide would induce decreases in intake accompanied by changes in proportional food or macronutrient intake similar to those
seen following RYGB in rats when a variety of palatable food options are available. A "cafeteria diet" was used that included: chow,
refried beans (low-fat/low-sugar), low-fat yogurt (low-fat/high-sugar), peanut butter (high-fat/low-sugar) and sugar-fat whip
(high-fat/high-sugar). Liraglutide (1 mg/kg daily, sc, n=6) induced significant reductions in body weight and total caloric intake
compared to saline–injected control rats (n=6). Although access to a cafeteria diet induced increases in caloric intake in both groups
relative to chow alone, liraglutide still effectively decreased intake compared with saline-injected rats suggesting that chronic GLP-1
activation competes with the energy density and palatability of available food options in modulating ingestive behavior. Even with the
substantial effects on overall intake, liraglutide did not change food choice or relative macronutrient intake when compared to
pre-treatment baseline. When drug treatment was discontinued, the liraglutide group increased caloric intake and rapidly gained body
weight to match that of the saline group. These results demonstrate that, while liraglutide effectively decreases caloric intake and body
weight in rats, it does not cause adjustments in relative macronutrient consumption, suggesting that such changes seen after RYGB are
unlikely due to activation of the GLP-1 receptor system alone. / A Thesis submitted to the Department of Psychology in partial fulfillment of the requirements for the
degree of Master of Science. / Fall Semester 2016. / November 22, 2016. / Food Choice, GLP-1, Roux-en-Y Gastric Bypass, Taste Preference, Weight Loss / Includes bibliographical references. / Alan C. Spector, Professor Directing Thesis; Pamela Keel, Committee Member; Diana Williams,
Committee Member.
| Identifer | oai:union.ndltd.org:fsu.edu/oai:fsu.digital.flvc.org:fsu_405660 |
| Contributors | Hyde, Kellie (authoraut), Spector, Alan C. (professor directing thesis), Keel, Pamela K. (committee member), Williams, Diana L (committee member), Florida State University (degree granting institution), College of Arts and Sciences (degree granting college), Department of Psychology (degree granting departmentdgg) |
| Publisher | Florida State University, Florida State University |
| Source Sets | Florida State University |
| Language | English, English |
| Detected Language | English |
| Type | Text, text |
| Format | 1 online resource (41 pages), computer, application/pdf |
| Rights | This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). The copyright in theses and dissertations completed at Florida State University is held by the students who author them. |
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