Extracellular vesicles derived from mesenchymal stem cells (MSC-EVs) have demonstrated to be neuroprotective and an excellent candidate for the treatment of cortical injury. In our laboratory, it was demonstrated the enhancement of motor recovery after cortical motor injury on a rhesus monkey model. This study will build on those findings and provide an in-depth examination of the nature and rate of recovery function specifically looking at the slope of recovery comparing the vehicle and MSC-EVs treated group. The monkeys were trained on the Hand-Dexterity Test (HDT), a fine motor task, for four weeks prior to induced cortical injury on hand representation on the contralateral primary motor cortex of the dominant hand. The monkeys received vehicle or MSC-EVs treatment 24 hours and 14 days after injury. The post-operative HDT test was performed to analyze the recovery of motor function of both impaired dominant-hand and non-impaired non-dominant hand on both large and small wells of the testing apparatus. Both the vehicle and MSC-EVs group demonstrated a positive recovery slope. The non-dominant hand for the large well also showed to be significantly different (p = 0.01) when comparing in between MSC-EVs treated and vehicle groups. These results support previous findings from our lab, reinforce that MSC-EVs to be potentially used as a clinical treatment, and demonstrate an important approach to the non-impaired hand recovery to be analyzed in future cell therapy studies.
| Identifer | oai:union.ndltd.org:bu.edu/oai:open.bu.edu:2144/43758 |
| Date | 01 February 2022 |
| Creators | Zuim Dantas de Souza, Raissa |
| Contributors | Moore, Tara L. |
| Source Sets | Boston University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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