Personalized medicine, the individualization of clinical care based, in part, upon an individuals genetic background, can be thought of as a three step process: scientific discovery, validation, and clinical implementation. Women and individuals of diverse ethnic/racial backgrounds are at risk of widening health disparities unless additional emphasis is placed upon these subjects for future research. Genetic association studies were used to identify genetic variants that contribute to the timing of the reproductive lifespan in women, endometrial cancer, and elevated serum thyroid stimulating hormone levels. A rapid evidence review was performed to validate previously reported variants associated with hypothyroidism and consider the analytic evidence that genetic testing of asymptomatic adult women leads to improved health outcomes. The ethical, legal, and social impacts of personalized medicine implementation were evaluated from the perspectives of both the health care system and the general public.
| Identifer | oai:union.ndltd.org:VANDERBILT/oai:VANDERBILTETD:etd-10262014-201331 |
| Date | 31 October 2014 |
| Creators | Malinowski, Jennifer Renee |
| Contributors | Digna Velez-Edwards, Ph.D., Ellen Wright Clayton, MD, JD, Melinda Aldrich, Ph.D., M.P.H., Dana C. Crawford, Ph.D., William S. Bush, Ph.D., M.S. |
| Publisher | VANDERBILT |
| Source Sets | Vanderbilt University Theses |
| Language | English |
| Detected Language | English |
| Type | text |
| Format | application/pdf |
| Source | http://etd.library.vanderbilt.edu/available/etd-10262014-201331/ |
| Rights | restricted, I hereby certify that, if appropriate, I have obtained and attached hereto a written permission statement from the owner(s) of each third party copyrighted matter to be included in my thesis, dissertation, or project report, allowing distribution as specified below. I certify that the version I submitted is the same as that approved by my advisory committee. I hereby grant to Vanderbilt University or its agents the non-exclusive license to archive and make accessible, under the conditions specified below, my thesis, dissertation, or project report in whole or in part in all forms of media, now or hereafter known. I retain all other ownership rights to the copyright of the thesis, dissertation or project report. I also retain the right to use in future works (such as articles or books) all or part of this thesis, dissertation, or project report. |
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