Parkinson’s Disease is a neurological degenerative disease affecting more than six million people worldwide. It is a progressive disease, impacting a person’s movements and thought processes. In recent years, computer vision and machine learning researchers have been developing techniques to aid in the diagnosis. This thesis is motivated by the exploration of hand tremor symptoms in Parkinson’s patients from the Archimedean Spiral test, a paper-and-pencil test used to evaluate hand tremors. This work presents a novel Fourier Domain analysis technique that transforms the pencil content of hand-drawn spiral images into frequency features. Our technique is applied to an image dataset consisting of spirals drawn by healthy individuals and people with Parkinson’s Disease. The Fourier Domain analysis technique achieves 81.5% accuracy predicting images drawn by someone with Parkinson’s, a result 6% higher than previous methods. We compared this method against the results using extracted features from the ResNet-50 and VGG16 pre-trained deep network models. The VGG16 extracted features achieve 95.4% accuracy classifying images drawn by people with Parkinson’s Disease. The extracted features of both methods were also used to develop a tremor severity rating system which scores the spiral images on a scale from 0 (no tremor) to 1 (severe tremor). The results show correlation to the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) developed by the International Parkinson and Movement Disorder Society. These results can be useful for aiding in early detection of tremors, the medical treatment process, and symptom tracking to monitor the progression of Parkinson’s Disease. / M.S. / Parkinson’s Disease is a neurological degenerative disease affecting more than six million people worldwide. It is a progressive disease, impacting a person’s movements and thought processes. In recent years, computer vision and machine learning researchers have been developing techniques to aid in the diagnosis. This thesis is motivated by the exploration of hand tremor symptoms in Parkinson’s patients from the Archimedean Spiral test, a paper-and-pencil test used to evaluate hand tremors. This work presents a novel spiral analysis technique that converts the pencil content of hand-drawn spirals into numeric values, called features. The features measure spiral smoothness. Our technique is applied to an image dataset consisting of spirals drawn by healthy and Parkinson’s individuals. The spiral analysis technique achieves 81.5% accuracy predicting images drawn by someone with Parkinson’s. We compared this method against the results using extracted features from pre-trained deep network models. The VGG16 pre-trained model extracted features achieve 95.4% accuracy classifying images drawn by people with Parkinson’s Disease. The extracted features of both methods were also used to develop a tremor severity rating system which scores the spiral images on a scale from 0 (no tremor) to 1 (severe tremor). The results show a similar trend to the tremor evaluations rated by the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) developed by the International Parkinson and Movement Disorder Society. These results can be useful for aiding in early detection of tremors, the medical treatment process, and symptom tracking to monitor the progression of Parkinson’s Disease.
| Identifer | oai:union.ndltd.org:VTETD/oai:vtechworks.lib.vt.edu:10919/115350 |
| Date | 05 1900 |
| Creators | DeSipio, Rebecca E. |
| Contributors | Electrical and Computer Engineering, Abbott, A. Lynn, Buehrer, Michael, Jia, Ruoxi |
| Publisher | Virginia Tech |
| Source Sets | Virginia Tech Theses and Dissertation |
| Language | English |
| Detected Language | English |
| Type | Thesis |
| Format | ETD, application/pdf, application/pdf |
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