Neuroendocrine tumours generally show an overexpression of somatostatin receptors on their cell membranes, mainly subtype 2. This is taken advantage of in diagnosis and therapy by using synthetic somatostatin analogues that can be labelled with radionuclides to visualize and treat tumours with an overexpression of somatostatin receptors. The method traditionally used for visualization is somatostatin receptor scintigraphy (SRS) with 111In-DTPA-octreotide but this method is gradually being substituted by 68Ga-DOTATOC PET/CT. To evaluate patients for peptide receptor radionuclide therapy, it is mandatory for the patient to be examined by both methods. In the evaluation, the tumours are graded according to the Krenning scale on the images from the SRS. Patients with sufficient tumour uptake of somatostatin analogues are eligible for peptide receptor radionuclide therapy (PRRT). The aim of this study was to compare the tumour’s Krenning scores from SRS to the Krenning scores, quantitative indices and TNR-values from the 68Ga-DOTATOC PET/CT images. This was done to investigate if the Krenning scale could be applied to PET/CT enabling the patient to undergo only PET/CT for diagnosis and evaluation prior to PRRT. This study, including 28 patients, found no strong correlation between the Krenning scores from the SRS and the scores from 68Ga-DOTATOC PET/CT. However, a better correlation was shown between the Krenning scores from SRS and TNR-values where the quantitative indices SUVmax and SUVmean were divided with the SUVmean of the spleen. These findings could be worth exploring further in future studies, incorporating larger number of patients.
| Identifer | oai:union.ndltd.org:UPSALLA1/oai:DiVA.org:uu-506042 |
| Date | January 2018 |
| Creators | Wenngren, Josefin |
| Publisher | Uppsala universitet, Institutionen för kvinnors och barns hälsa |
| Source Sets | DiVA Archive at Upsalla University |
| Language | Swedish |
| Detected Language | English |
| Type | Student thesis, info:eu-repo/semantics/bachelorThesis, text |
| Format | application/pdf |
| Rights | info:eu-repo/semantics/openAccess |
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