In these studies, a procedure which allowed the in vivo labeling and detection of poly(ADP-ribose) was combined with nuclear fractionation techniques to analyze the nuclear distribution of ADP-ribose polymers. The results from these studies suggest the occurrence of poly(ADP-ribose) metabolism in two compartments of chromatin; one that is nuclear matrix-associated and one that is not. The biological significance of this compartmentalization is conceptualization in a model. This model postulates that, under some physiological conditions, poly(ADP-ribose) metabolism accomplishes the reversible targeting of specific regions of chromatin to the nuclear matrix domain by modulating DNA-protein and or protein-protein interactions.
| Identifer | oai:union.ndltd.org:unt.edu/info:ark/67531/metadc798380 |
| Date | 08 1900 |
| Creators | Cárdenas-Corona, María E. (María Elena) |
| Contributors | Jacobson, Myron, Benjamin, Robert C., Pirtle, Robert M., Harris, Ben G., Wimbish, Gary Harold, Wu, Edward |
| Publisher | University of North Texas |
| Source Sets | University of North Texas |
| Language | English |
| Detected Language | English |
| Type | Thesis or Dissertation |
| Format | xi, 163 leaves : ill., Text |
| Rights | Public, Cárdenas-Corona, María E. (María Elena), Copyright, Copyright is held by the author, unless otherwise noted. All rights |
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