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Effects of Cholinergic Depletion on Neural Activity in Different Laminae of the Rat Barrel Cortex

The purpose of these experiments was to determine the effects of cholinergic depletion on spontaneous and evoked activity of neurons in the different layers of the posteromedial barrel subfield (PMBSF) of the rat somatosensory cortex. Acetylcholine neurons in nucleus basalis of Meynert (NBM) were selectively lesioned with an immunotoxin (IT), 192 IgG-saporin. Spontaneous activity was significantly lower in layers II-III, Va, and VI in IT-injected animals compared to control animals. Evoked activity was significantly lower in layers II-III, IV, Vb, and VI of IT-injected animals compared to control animals. The largest difference was observed in layer Vb. Thus, cholinergic depletion causes significant changes in the magnitude of spontaneous and evoked activity but these differences are not completely in register with one another.

Identiferoai:union.ndltd.org:ETSU/oai:dc.etsu.edu:etsu-works-15791
Date28 July 2000
CreatorsHerron, Paul, Schweitzer, John B.
PublisherDigital Commons @ East Tennessee State University
Source SetsEast Tennessee State University
Detected LanguageEnglish
Typetext
SourceETSU Faculty Works

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