Epidemiological studies have suggested that the consumption
of fish may reduce the risk of cardiovascular disease.
Compared to the number of studies using fish oils, few
studies have used fish itself. Those which have used fish
have generally used fattier fish such as mackerel and salmon
as part of an uncontrolled diet. In this study, 23 healthy
men consumed 200g each of Chinook salmon, Dover sole, and
sablefish in a three-way crossover design for 18-day periods
with three-week washout periods in between. The diets had
the approximate composition of the 'Western' diet: 45%
carbohydrates, 36% fat, and 16% protein with the sole diet
containing 1.95 g omega-3 (n-3) fatty acids, the salmon diet
3.99 g n-3, and the sablefish diet 3.42 g n-3 fatty acids.
Serum total cholesterol (TC), high density lipoprotein
cholesterol (HDL-C), low density lipoprotein cholesterol
(LDL-C), triglycerides (TG), bleeding time (BT), blood
pressure (BP), platelet aggregation (PA) using ADP and
collagen as agonists, platelet fatty acid profiles (FAP), thromboxane B2 (TXB2) , and apolipoprotein B (Apo B) were
measured at the beginning and end of each period. TC, and
HDL-C, and TG changed significantly when compared to the
prefish diet while both LDL-C and apo B demonstrated diet
effect. LDL-C increased on both the salmon and sablefish
diets (p = 0.08) compared to the sole diet, and increased
approximately 15% on the former two diets compared to the
prefish diet. Bleeding time was significantly longer when
the salmon diet was consumed (p = 0.06). The impact of the
three diets on PA depended upon the agonist. With collagen,
only the sablefish diet decreased aggregation compared to
the prefish diet. When ADP was used, aggregation decreased
on both the fattier fish diets compared to the low fat fish
(sole). Similar results were demonstrated for TXB₂: the
fattier fish produced statistically equivalent decreases (p
= 0.06) among the diets, and lowered TXB₂ compared to the
prefish diet. There were no significant differences among
the diets for either systolic or diastolic BP though there
was a significant decrease (p = 0.01) in diastolic pressure
compared to the prefish diet when the salmon diet was
consumed. Platelet fatty acid profiles reflected diet
composition. / Graduation date: 1993
| Identifer | oai:union.ndltd.org:ORGSU/oai:ir.library.oregonstate.edu:1957/27085 |
| Date | 08 December 1992 |
| Creators | Patton, Beverly D. |
| Contributors | Wander, Rosemary C. |
| Source Sets | Oregon State University |
| Language | en_US |
| Detected Language | English |
| Type | Thesis/Dissertation |
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