abstract: CpG methylation is an essential requirement for the normal development of mammals, but aberrant changes in the methylation can lead to tumor progression and cancer. An in-depth understanding of this phenomenon can provide insights into the mechanism of gene repression. We present a study comparing methylated DNA and normal DNA wrt its persistence length and contour length. Although, previous experiments and studies show no difference between the physical properties of the two, the data collected and interpreted here gives a different picture to the methylation phenomena and its effect on gene silencing. The study was extended to the artificially reconstituted chromatin and its interactions with the methyl CpG binding proteins were also probed. / Dissertation/Thesis / Ph.D. Physics 2012
| Identifer | oai:union.ndltd.org:asu.edu/item:15236 |
| Date | January 2012 |
| Contributors | Kaur, Parminder (Author), Lindsay, Stuart (Advisor), Ros, Robert (Committee member), Tao, Nongjian (Committee member), Vaiana, Sara (Committee member), Beckenstein, Oliver (Committee member), Arizona State University (Publisher) |
| Source Sets | Arizona State University |
| Language | English |
| Detected Language | English |
| Type | Doctoral Dissertation |
| Format | 175 pages |
| Rights | http://rightsstatements.org/vocab/InC/1.0/, All Rights Reserved |
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