Yes / The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene
complexes is described. The chemical structure and physical properties of the nanoparticles were characterised
by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR),
1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray
powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that
caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated
that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such
well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for
example in drug delivery. / We thank the National Natural Science Foundation of China (Project No. 21571154), the Jiangsu Overseas Research & Training Program for University Prominent Young & Middle-aged Teachers and Presidents, Leverhulme Trust (Early Career Fellowship No. ECF-2013-414 to NPEB), the ERC (Grant No. 247450 to PJS), EPSRC (EP/F034210/1 to PJS) and Science City (AWM/ERDF) for support, and EU COST Action CM1105 for stimulating discussions.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/11262 |
| Date | 21 June 2016 |
| Creators | Wang, Y., Pitto-Barry, Anaïs, Habtemariam, A., Romero-Canelón, I., Sadler, P.J., Barry, Nicolas P.E. |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Article, Published version |
| Rights | © 2016 The Royal Society of Chemistry. Reproduced in accordance with the publisher's self-archiving policy. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence., CC-BY |
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