Perfluoro-4-isopropylpyridine has been shown to undergo nucleophilic substitution reactions with wide range of nucleophiles and was thus demonstrated to behave as a powerful regioselective electrophile in most cases. This work has enabled a series of highly fluorinated macrocyclic compounds to be synthesised based on highly fluorinated pyridine derivatives. Polyfluoroalkylation and nucleophilic substitution in tetrafluoropyrimidine and tetrafluorophthalonitrile give highly fluorinated products that react readily with nucleophiles.
| Identifer | oai:union.ndltd.org:bl.uk/oai:ethos.bl.uk:369693 |
| Date | January 2001 |
| Creators | Richmond, Paul |
| Publisher | Durham University |
| Source Sets | Ethos UK |
| Detected Language | English |
| Type | Electronic Thesis or Dissertation |
| Source | http://etheses.dur.ac.uk/3797/ |
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